Okay then, i use quite a few Nautiluses myself, generally they're foolproof, bar the coils at times. Aspire's QC is sometimes wayward, so first thing is replace the coil for a new one.
If that doesn't work, check the metal base unit (the bit the coil screws on to at the bottom of the tank) and make sure it isn't gunked up wth old juice. Plus check that the tiny contact pin in the base is still fully intact as this contacts the coil to the battery pack. I mention this, because recently the contact pin in my Nautilus Mini, had partially broken off, therefor the coil wasn't quite making a proper connection to the mod pack. This resulted in some coils burning out too quickly, or occasionally the screen showing 'no atomiser detected'. I was quite amazed that such a tiny bit of metal could cause that much of a problem for the coil!
Thirdly: you don't mention what mod it's on, but how old is it? Sometimes a well used mod, can start to malfunction, so if you're still haveing probs after doing the basics, try the tank on a different mod (if you have another to try on) that you know does work, and see what that does.
Hopefully it's just a knackered coil or tank base needs a clean.