Right the Engineers Two penny worth,
All cylindrical cells currently used for vaping vent through the positive cap. Most mechanical mods vent at the switch end - therefore logic would dictate that you insert the cell with the positive closest to the vent holes. Cells are constucted with the outer case being the negative pole of the cell, this is covered with a wrapper both to protect the cell from short circuits and to display information / branding - If you insert a cell with the positive to the switch end of a tube / all metal mod and the wrapper becomes damaged pressing the switch will result in a hard short, a very hot button and lots of swearing, shortly followed by the cell venting if you keep the button pressed. Whilst this is not the ideal way to fit cells in a tube / all metal mod it is slightly safer than positive end first as the vents will not get obstructed in the event of a cell venting. Ideally you should not use any device where the cell can swell and block the vents...
Personally I think mechanical mods are for those experienced enough at building coils and who know the risks involved with Lithium cells. Anyone else should start with regulated mods, learn about rebuilding and battery safety - then buy a mechanical box mod that is designed in such a way that cells won't short (Ones with actual battery holders) to get used to battery safety with mechs - then once they know the risks they can buy any damn thing they please and if they blow their hand off then they have no one but themselves to blame
Here endeth the gospel according to Tubby...