No - the measuring is simple with the help of the POTV app - you fill in your nic base strength and base type, what end quantity, strength and PG/VG ratio you want, what flavour percentage you're going to add, and it'll tell you exactly how much of everything to add.
The flavour blending is more intuitive, but best thing to do is just go for it. Start with single flavours if you want to get comfortable with the rest of it, then advance to pairing up a couple, then the sky's the limit.
I ordered my ingredients the day after I got my first CE4/Ego kit and was mixing my own within the week.