Not charging to 100% puts less stress on the cells.
In the battery tab there's a tab for "maximise puffs" or "maximise recharges". The second option drops capacity to around 4.1v per cell. On older non colour boards it's less important from what I've seen. More important, especially for C variants is to set cut off no lower than 3v if using the mod & disconnect from board if not being used for any length of time. The board still drains the battery pack and on LiPos going too low it's a pain trying to recover the cells. Goosed one LiPo pack because voltage had dropped to around 2v & couldn't be recharged.
That's exactly what I do (even if I am using standard Li-Ion batteries).
I have a small collection of DNA based mods:
1. 75c: Therion, Therion BF, Thor, Thor II
2. 250c: Paranormal, Triade, Drone
3. 100c: Hyperion (and Thelema Solo is on the way).
As you described, the "maximise recharge" set in Escribe puts the limit to something around 4.1V in the pretty similar way what my last phone does, stooping charging at 80%.
Cutout voltage is set on 3.1V.
Regarding the board drain: yes, even the clock consumes some power but I have noticed that the drone (2x18650, NDA250C) was around 80% while it was not in sue for some 2 months now.